Electrochemotherapy of chest wall breast cancer recurrence.
Identifieur interne : 004343 ( Main/Exploration ); précédent : 004342; suivant : 004344Electrochemotherapy of chest wall breast cancer recurrence.
Auteurs : Gregor Sersa [Slovénie] ; Tanja Cufer ; Snezna Marija Paulin ; Maja Cemazar ; Marko SnojSource :
- Cancer treatment reviews [ 1532-1967 ] ; 2012.
Descripteurs français
- KwdFr :
- Bléomycine (administration et posologie), Bléomycine (usage thérapeutique), Cisplatine (administration et posologie), Cisplatine (usage thérapeutique), Femelle, Humains, Paroi thoracique (anatomopathologie), Récidive tumorale locale (), Récidive tumorale locale (radiothérapie), Récidive tumorale locale (traitement médicamenteux), Résultat thérapeutique, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie), Tumeurs du sein (traitement médicamenteux), Tumeurs du thorax (anatomopathologie), Tumeurs du thorax (traitement médicamenteux), Électrochimiothérapie (), Électrochimiothérapie (effets indésirables).
- MESH :
- administration et posologie : Bléomycine, Cisplatine.
- anatomopathologie : Paroi thoracique, Tumeurs du sein, Tumeurs du thorax.
- effets indésirables : Électrochimiothérapie.
- radiothérapie : Récidive tumorale locale, Tumeurs du sein.
- traitement médicamenteux : Récidive tumorale locale, Tumeurs du sein, Tumeurs du thorax.
- usage thérapeutique : Bléomycine, Cisplatine.
- Femelle, Humains, Récidive tumorale locale, Résultat thérapeutique, Tumeurs du sein, Électrochimiothérapie.
English descriptors
- KwdEn :
- Bleomycin (administration & dosage), Bleomycin (therapeutic use), Breast Neoplasms (drug therapy), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Cisplatin (administration & dosage), Cisplatin (therapeutic use), Electrochemotherapy (adverse effects), Electrochemotherapy (methods), Female, Humans, Neoplasm Recurrence, Local (drug therapy), Neoplasm Recurrence, Local (radiotherapy), Neoplasm Recurrence, Local (surgery), Thoracic Neoplasms (drug therapy), Thoracic Neoplasms (pathology), Thoracic Wall (pathology), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Bleomycin, Cisplatin.
- chemical , therapeutic use : Bleomycin, Cisplatin.
- adverse effects : Electrochemotherapy.
- drug therapy : Breast Neoplasms, Neoplasm Recurrence, Local, Thoracic Neoplasms.
- methods : Electrochemotherapy.
- pathology : Breast Neoplasms, Thoracic Neoplasms, Thoracic Wall.
- radiotherapy : Breast Neoplasms, Neoplasm Recurrence, Local.
- surgery : Breast Neoplasms, Neoplasm Recurrence, Local.
- Female, Humans, Treatment Outcome.
Abstract
Chest wall breast cancer recurrence after mastectomy is a disease difficult to treat. Its incidence varies between 5% and 30% in different subset of patients. When possible, radical surgical therapy represents the main treatment approach, however when the disease progresses and/or treatments are not successful, ulceration, bleeding, lymphedema and psychological distress of progressive disease significantly decrease the quality of the remaining life of a patient. When surgical excision of chest wall recurrence is not possible, other local treatments such as radiotherapy, radiotherapy with hyperthermia, topical chemotherapy and electrochemotherapy might be taken into account. Electrochemotherapy provides safe, efficient and non-invasive locoregional treatment approach for chest wall breast cancer recurrence. Several clinical studies have demonstrated high efficacy and a good safety profile of electrochemotherapy applied in single or multiple consecutive sessions, till clinical response was reached. Electrochemotherapy can be performed either with cisplatin injected intratumorally or with bleomycin given intratumorally or intravenously. Furthermore, it can be effectively used in heavily pre-treated areas, after surgery, radiotherapy or systemic chemotherapy. These are the advantages that might demand its use especially in patients with pre-treated extensive disease and in frail elderly patients. With development of the technology electrochemotherapy could even be suggested as a primary local therapy in patients not suitable for surgical removal of the primary tumor.
DOI: 10.1016/j.ctrv.2011.07.006
PubMed: 21856080
Affiliations:
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Le document en format XML
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first="Snezna Marija" last="Paulin">Snezna Marija Paulin</name></author><author><name sortKey="Cemazar, Maja" sort="Cemazar, Maja" uniqKey="Cemazar M" first="Maja" last="Cemazar">Maja Cemazar</name></author><author><name sortKey="Snoj, Marko" sort="Snoj, Marko" uniqKey="Snoj M" first="Marko" last="Snoj">Marko Snoj</name></author></analytic><series><title level="j">Cancer treatment reviews</title><idno type="eISSN">1532-1967</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bleomycin (administration & dosage)</term><term>Bleomycin (therapeutic use)</term><term>Breast Neoplasms (drug therapy)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (radiotherapy)</term><term>Breast Neoplasms (surgery)</term><term>Cisplatin (administration & dosage)</term><term>Cisplatin (therapeutic use)</term><term>Electrochemotherapy (adverse effects)</term><term>Electrochemotherapy (methods)</term><term>Female</term><term>Humans</term><term>Neoplasm Recurrence, Local (drug therapy)</term><term>Neoplasm Recurrence, Local (radiotherapy)</term><term>Neoplasm Recurrence, Local (surgery)</term><term>Thoracic Neoplasms (drug therapy)</term><term>Thoracic Neoplasms (pathology)</term><term>Thoracic Wall (pathology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Bléomycine (administration et posologie)</term><term>Bléomycine (usage thérapeutique)</term><term>Cisplatine (administration et posologie)</term><term>Cisplatine (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Paroi thoracique (anatomopathologie)</term><term>Récidive tumorale locale ()</term><term>Récidive tumorale locale (radiothérapie)</term><term>Récidive tumorale locale (traitement médicamenteux)</term><term>Résultat thérapeutique</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (radiothérapie)</term><term>Tumeurs du sein (traitement médicamenteux)</term><term>Tumeurs du thorax (anatomopathologie)</term><term>Tumeurs du thorax (traitement médicamenteux)</term><term>Électrochimiothérapie ()</term><term>Électrochimiothérapie (effets indésirables)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Bleomycin</term><term>Cisplatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bleomycin</term><term>Cisplatin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Bléomycine</term><term>Cisplatine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electrochemotherapy</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Paroi thoracique</term><term>Tumeurs du sein</term><term>Tumeurs du thorax</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term><term>Neoplasm Recurrence, Local</term><term>Thoracic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Électrochimiothérapie</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electrochemotherapy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Thoracic Neoplasms</term><term>Thoracic Wall</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Récidive tumorale locale</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Récidive tumorale locale</term><term>Tumeurs du sein</term><term>Tumeurs du thorax</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Bléomycine</term><term>Cisplatine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Récidive tumorale locale</term><term>Résultat thérapeutique</term><term>Tumeurs du sein</term><term>Électrochimiothérapie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chest wall breast cancer recurrence after mastectomy is a disease difficult to treat. Its incidence varies between 5% and 30% in different subset of patients. When possible, radical surgical therapy represents the main treatment approach, however when the disease progresses and/or treatments are not successful, ulceration, bleeding, lymphedema and psychological distress of progressive disease significantly decrease the quality of the remaining life of a patient. When surgical excision of chest wall recurrence is not possible, other local treatments such as radiotherapy, radiotherapy with hyperthermia, topical chemotherapy and electrochemotherapy might be taken into account. Electrochemotherapy provides safe, efficient and non-invasive locoregional treatment approach for chest wall breast cancer recurrence. Several clinical studies have demonstrated high efficacy and a good safety profile of electrochemotherapy applied in single or multiple consecutive sessions, till clinical response was reached. Electrochemotherapy can be performed either with cisplatin injected intratumorally or with bleomycin given intratumorally or intravenously. Furthermore, it can be effectively used in heavily pre-treated areas, after surgery, radiotherapy or systemic chemotherapy. These are the advantages that might demand its use especially in patients with pre-treated extensive disease and in frail elderly patients. With development of the technology electrochemotherapy could even be suggested as a primary local therapy in patients not suitable for surgical removal of the primary tumor.</div></front></TEI><affiliations><list><country><li>Slovénie</li></country></list><tree><noCountry><name sortKey="Cemazar, Maja" sort="Cemazar, Maja" uniqKey="Cemazar M" first="Maja" last="Cemazar">Maja Cemazar</name><name sortKey="Cufer, Tanja" sort="Cufer, Tanja" uniqKey="Cufer T" first="Tanja" last="Cufer">Tanja Cufer</name><name sortKey="Paulin, Snezna Marija" sort="Paulin, Snezna Marija" uniqKey="Paulin S" first="Snezna Marija" last="Paulin">Snezna Marija Paulin</name><name sortKey="Snoj, Marko" sort="Snoj, Marko" uniqKey="Snoj M" first="Marko" last="Snoj">Marko Snoj</name></noCountry><country name="Slovénie"><noRegion><name sortKey="Sersa, Gregor" sort="Sersa, Gregor" uniqKey="Sersa G" first="Gregor" last="Sersa">Gregor Sersa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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